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KMID : 1161420180210030269
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Journal of Medicinal Food
2018 Volume.21 No. 3 p.269 ~ p.273
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Alpha-Lipoic Acid Shows Promise to Improve Migraine in Patients with Insulin Resistance: A 6-Month Exploratory Study
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Cavestro Cinzia
Bedogni Giorgio
Molinari Filippo
Mandrino Silvia
Rota Eugenia
Frigeri Maria Cristina
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Abstract
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Alpha-lipoic acid (ALA) is known to lower insulin resistance (IR), which is common among migraineurs. To assess the effect of ALA on headache in migraineurs with IR, we performed an exploratory study on a cohort of patients with migraine, followed at our Headache Center. The 32 patients took ALA 400?mg b.i.d. for 6 months in addition to their on-going treatment. The percentage of patients with a reduction of at least 50% of the attacks was 0.53 (confidence interval [95% CI] 0.36?0.70) at 2 months, 0.56 (0.39?0.73) at 4 months, and 0.69 (0.53?0.85) at 6 months. The incidence rate ratio of attacks at 6 months versus baseline was 0.48 (0.43?0.53, P?
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KEYWORD
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alpha-lipoic acid, cohort study, glucose, insulin resistance, insulin sensitivity, migraine, oral glucose tolerance testing
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